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Clinical Trials Experience in Pediatric Subjects with Chronic HBV Infection.

Lamivudine is predominantly eliminated in the urine by active organic cationic secretionThe possibility of interactions with other drugs administered concurrently should be consideredparticularly when their main route of elimination is active renal secretion via the organic cationic transport systeme.gtrimethoprimsee Clinical Pharmacology12.3No data are available regarding interactions with other drugs that have renal clearance mechanisms similar to that of lamivudine.

Severe acute exacerbations of hepatitis B have been reported in patients who have discontinued anti-hepatitis B therapyincluding Epivir-HBVHepatic function should be monitored closely with both clinical and laboratory follow-up for at least several months in patients who discontinue anti-hepatitis B therapyIf appropriateinitiation of antihepatitis B therapy may be warrantedsee Warnings and Precautions5.2

Lactic acidosis and steatosissee Warnings and Precautions5.1posttreatment exacerbations of hepatitissee Warnings and Precautions5.2pancreatitis.

Use this medicine regularly in order to get the most benefit from itThis medication works best when the amount of drug in your body is kept at a constant levelRemember to use it at the same time each dayDo not skip any dosesDosage is based on your medical condition and response to therapy.

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